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How To Minimize Your Reaction to Allergy Shots

Allergy shots, AKA allergen immunotherapy, can sometimes trigger allergic reactions. Dr. Mark Aronica of the Cleveland Clinic tells us how to lessen the impact of these shots while providing...

Allergy shots, AKA allergen immunotherapy, can sometimes trigger allergic reactions. Dr. Mark Aronica of the Cleveland Clinic tells us how to lessen the impact of these shots while providing relief to those allergies to improve quality of life by reducing symptoms and side effects.

How To Minimize Your Reaction to Allergy Shots

January 20, 2023

Your medicine cabinet is loaded with antihistamines, and you never go anywhere without a package (or three) of tissues. Maybe your healthcare provider has even suggested allergy shots. This lesser-known treatment for allergies can relieve the sneezy, itchy and watery torture caused by allergens. Some people even see their symptoms disappear entirely.

Known as allergen immunotherapy, allergy shots help treat common allergies to substances such as pollen, dust mites, pet dander and mold spores. They may also be helpful if you’re allergic to the venom from certain stinging insects, like bees, hornets, wasps and yellow jackets.

But maybe you’ve heard that people have negative reactions to these shots. Allergy specialist Mark Aronica, MD, explains why this happens, what to watch for and how you may be able to prevent reactions from allergy shots.

What are allergy shots?

Allergy shots are a treatment for allergies that introduce very small amounts of allergens into your body via injection (shot). Your provider tailors your specific cocktail of allergens in the shots, depending on what allergies you have.

“The shots are a form of immunotherapy that help decrease or even stop allergy symptoms,” Dr. Aronica explains.

By exposing your body to the tiny amounts of allergens in the shots, you build up a tolerance to them. Then, your body doesn’t react as strongly to the allergens when you encounter them in your life, like during allergy season.

This treatment requires many shots, usually weekly, over a period of years. Your provider slowly increases the amount of allergens in the shot. Once you’ve reached the maintenance phase (the highest dose), you’ll need to get the shots less often.

Why does an allergy shot reaction happen?

A course of allergy shots always starts out with very tiny doses of the allergens. The goal is to stimulate your immune system enough to recognize the allergens but not cause a serious reaction.

But negative reactions to allergy shots sometimes happen.

“We’re giving people things they’re allergic to, and there’s always that risk of a negative reaction,” Dr. Aronica says. “Done appropriately, allergy shots desensitize the person to the allergen trigger. But sometimes, their body reacts too strongly to the allergens in the shot.”

The most common allergy shot reactions

Reactions can range from very minor swelling at the site of the shot to life-threatening anaphylaxis. But Dr. Aronica notes, “Serious reactions to allergy shots are less common — generally considered to be less than 1%.”

The most common reaction to allergy shots is swelling at the injection site. This swelling can range from pea-sized to golf ball-sized, but it’s usually gone within 48 hours. You may also experience itching and/or hives over large parts of your body.

Less common but more serious reactions include:

  • Trouble breathing, like chest tightness, wheezing and/or shortness of breath.
  • A drop in blood pressure accompanied by dizziness and/or fainting.
  • Hives that appear separate from the site of injection.

How long after allergy shots can you have a reaction?

“If you’re going to have a negative reaction, you’ll most likely have it within 30 minutes of the shot,” Dr. Aronica states. That’s why you’re required to wait 30 minutes before leaving your provider’s office. At the end of the 30 minutes, a provider checks you for any troublesome symptoms.

In very rare cases, someone can have a delayed reaction after an allergy shot up to a couple of hours later. Such reactions may range from mild to severe.

What about an allergy shot reaction the next day? “That would be extremely unusual,” Dr. Aronica says.

But to be safe, people on allergen immunotherapy get a prescription for an epinephrine autoinjector (EpiPen®) to keep on hand. This injection device is pre-filled with epinephrine, which treats severe allergic reactions.

Who’s at risk for allergy shot reactions?

People with asthma are at higher risk of a reaction to allergy shots.

“Stay on your asthma meds and make sure your asthma is well-controlled before having these shots,” Dr. Aronica advises. Before each shot, you’ll get a peak flow test, which measures how quickly air exits your lungs when you exhale. This test makes sure your asthma is under control.

If you’re on beta-blockers or other medicines for high blood pressure, you may also be at higher risk for a reaction.

But anyone can have a reaction to allergy shots, Dr. Aronica notes. “There’s really just no way to predict that ahead of time, which is why we have precautions in place.”

Tips for avoiding allergy shot reactions

Here are some things you can do to minimize your chance of an allergy shot reaction:

  • If you have asthma, tell your care provider. Keep your asthma under control by taking your medications as prescribed.
  • If you’re sick with a cold or respiratory infection, wait until you’re well to get your allergy shot.
  • Avoid vigorous exercise right after getting an allergy shot.
  • Take an antihistamine before your shot, following your care provider’s instructions.

“Once you’ve reached the maintenance phase in your course of allergy shots, your risk of a reaction goes down significantly,” Dr. Aronica says. And though it may be inconvenient to get weekly shots over many months or years, you’ll likely see big-time relief from your allergies if you stick with the treatment.